「塑化劑常見於一般的塑膠製品，特別是 PVC 製品。
孩童長期大量暴露塑化劑，在女童會引起性早熟及乳房提早發育，性早熟的女童以後罹患乳癌、肥胖及心臟血管疾病的風險會上升。
男童長期暴露塑化劑會引起女性化的頃向，造成行為偏差，塑化劑還有睪丸的生殖毒性，男童成長後精子稀少活動力弱，易不孕。
塑化劑過度暴露，孩童也容易產生氣喘、過敏性疾病。」
Background
Parabens may be added to cosmetic and personal care products for preservation purposes. Low-molecular weight (LMW) phthalate diesters function as plasticizers, fixatives or solvents in such products, but may also be found in small quantities as contaminants from plastic containers.
Objective
To evaluate the association between emollient use, atopic dermatitis and FLG mutations, respectively, with urinary concentrations of phthalate metabolites and parabens in Danish children.
Methods
Results
The prevalence of atopic dermatitis was 16.1%. Phthalate metabolite and paraben levels were generally higher in children with frequent use of emollients compared to uncommon users, reaching statistical significance for some LMW phthalates and parabens. While there was no association with common FLG mutations, children with atopic dermatitis had significantly higher urinary levels of one LMW phthalate and two parabens, respectively, when compared to children without atopic dermatitis.
Conclusion
Emollient use and atopic dermatitis were associated with modestly increased internal LMW phthalate and paraben exposure in 4-9 year old children. It is unknown whether the difference is explained by increased use of the specific emollients that are used to treat pruritic and inflamed skin, and/or whether the impaired skin barrier allows chemicals to penetrate more easily. Moreover, the putative toxicological burden is unknown.
異位性皮膚炎，期刊研究，請看這裡。
其他期刊研究整理，請見這裡。
