WFU

2025年9月1日 星期一

只處理皮膚病灶就可以了嗎?普查近七萬名異位性皮膚炎病童:先合併新生兒熱痙攣、便祕、氣喘,接著是食物過敏、過敏性鼻炎、身心症、自體免疫疾病 - 韓國研究

作者:黃于家







本篇研究,"Cascade of atopic dermatitis comorbidities in children after birth for 15 years",請見這裡,期刊摘要如下:


Background:


Individuals with atopic dermatitis often develop other conditions.


Objective:


This study aimed to determine how atopic dermatitis comorbidities develop in children over time.


Methods:


This population-based administrative cohort study used national health insurance data. We traced individuals born in Korea between 2002 and 2003 to 2018. 

The date of initial atopic dermatitis diagnosis was set as the index date. Fifty-three childhood comorbidities of atopic dermatitis were identified as outcomes of interest by performing a comprehensive literature search and comparing the prevalence of diagnostic codes in children with and without atopic dermatitis. 

Four control children per individual in the atopic dermatitis group were randomly matched based on sex and index date. 

The association between atopic dermatitis and the development of each specified disease was assessed using proportional hazard assumption, followed by mapping of the temporal sequences of interconnected comorbidities.


Results:


The atopic dermatitis and control groups contained 67,632 and 270,528 individuals, respectively. The median age at the index date was 10 months, whereas the median follow-up period was 15 years. 

Twenty diseases that were associated with a higher risk of atopic dermatitis were identified and a chain of interconnected conditions created. 

The progression began in childhood with febrile seizures, constipation, and asthma, and was later associated with the emergence of food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.


Conclusion:


Our study highlights the temporal nature of atopic dermatitis comorbidities in children, and indicates that an understanding of the comorbidities may inform its clinical management and treatment.

異位性皮膚炎,中醫經方的治療實例,請見這裡

小兒異位性皮膚炎,中醫經方的治療實例,請見這裡

成人異位性皮膚炎,中醫經方的治療實例,請見這裡

異位性皮膚炎,期刊研究,請看這裡

期刊研究整理,請見這裡